Following PRISMA 2020 guidelines, we conducted a systematic review and meta-analysis, searching PubMed, Embase, Scopus, ScienceDirect, and Google Scholar up to January 2025. Eligible studies evaluated Toripalimab in esophageal cancer, including randomized controlled trials and non-randomized controlled trials. Primary outcomes included overall survival (OS), progression-free survival (PFS), and objective response rate (ORR), while safety outcomes assessed treatment-related adverse events. Data were synthesized using random-effects models, with heterogeneity evaluated via Cochrane’s Q and I² statistics.

• Ali dway

In total, 47 studies were included, encompassing 2,653 patients. Arthroscopic surgery resulted in a significant decrease in pain intensity for osteochondral lesions (MD = −4.49, P = .002) and ankle osteoarthritis (MD = −2.88, P = .034). Functional improvements were observed with notable success rates: 92.5% (soft tissue impingement), 87.5% (ankle synovitis), 73.2% (osteochondral lesions), 71.53% (bony impingement), and 54.7% (ankle osteoarthritis).

• Ali dway

Primary malignant lymphoma of the cervix is an extremely rare condition, accounting for only 0.008% of all cervical tumors and 2% of female extranodal lymphomas. The most common histological subtype is diffuse large B-cell lymphoma. This malignancy is often asymptomatic in its early stages, but advanced cases may include systemic symptoms, pelvic discomfort, and vaginal bleeding. Diagnosis is challenging due to its nonspecific clinical presentation and similarity to other gynecological conditions. Imaging and immunohistochemistry play essential roles in diagnosis and staging. Treatment typically involves chemotherapy, with the standard CHOP regimen for Non-Hodgkin’s lymphoma being the main treatment in most cases. To the best of our knowledge, this is the first case in the literature to describe acute kidney injury associated with the already rare entity of primary female genital tract lymphoma.

• Ram Attaf

About 90% of patients are symptomatic and hematuria is the most typical presenting symptom at diagnosis. The low incidence and the histopathologic similarities to adenocarcinoma from various sources pose a difficulty in recognizing the tumor. Our study presents the only case of a urachal carcinoma first manifesting with abdominal mass resulting from liver metastasis with no prior symptoms of urological origins. Also, our study presents the first attempt of using FLOFIRI-B to treat metastatic UraC.

• Ali dway

Pelvic fractures are often associated with significant morbidity, including injuries to the urinary tract. Understanding the incidence and risk factors for urinary tract injury in these patients is crucial for prompt diagnosis and management. This meta-analysis aims to synthesize existing evidence to determine the overall incidence and identify specific risk factors associated with urinary tract injuries in patients with pelvic fractures.

 

• Ali dway

Transcatheter aortic valve replacement (TAVR) is currently the treatment of choice for most patients with symptomatic severe aortic stenosis. We conducted this systematic review, and meta-analysis to compare the efficacy and procedural outcomes of using the cusp overlap technique (COT) versus the standard three-cusp technique during self-expandable valves implantation for the management of aortic stenosis.

• Ali dway

This systematic review and meta-analysis aim to evaluate the effectiveness of CBMs in treating Tourette syndrome.

• Ali dway

Healthcare is confronted by enormous challenges such as financial
and demographic changes, exponential technological progress,
an increasing incidence of chronically ill patients with changing
needs for care.
To meet these challenges and the associated changing of social
needs and expectations, our healthcare is constantly evolving.
When there is an acceleration or fault line in the variable care
needs, it is insufficient to make adjustments only to the current
models but also there is a need for a fundamental reform. If
health care is to be affordable, high-quality and accessible in
the future too, then the use of scarce resources is crucial. This
research focuses on the hospital of the future and the future of
the hospital within a larger healthcare system and consists of two
large sections.

• Mazen Abdel Rahman Fani

• sawsan ismail
• Kanaan Al-Tameemi

In conclusion, despite the proposition of several mechanisms underlying the development of AF post COVID-19 including the inflammatory cytokine storm, viral endothelial damage, electrolytes abnormalities, and the decrease in angiotensin-converting enzyme 2 receptor availability, the absence of the risk factors in our case and the limited number of similar cases highlight the necessity of further studies highlighting life-threatening arrhythmia in younger ages. More efforts and attention may be

• Kanaan Al-Tameemi
• sawsan ismail

Superior mesenteric artery syndrome is a rare morbid vascular disorder that is defined as the decreasing in the aortomesenteric angle and the compression of the third part of the duodenum. This disorder mainly affects young adult females, and severe weight loss represents a leading predisposing factor.

• sawsan ismail

Poorly differentiated thyroid carcinomas represent a rare heterogeneous group of malignant tumors that constitute approximately 2-4% of all thyroid neoplasms. Substernal Goiter is defined as an enlargement of the thyroid gland that is located below the thoracic inlet. Malignant neoplasms arising from a substernal goiter were reported in only 2-3% of cases.

This case report has been reported in line with the SCARE Criteria.

• sawsan ismail

Atypical Teratoid/Rhabdoid Tumor (AT/RT) is a rare aggressive neoplasm that mainly affects the pediatric population with a peak incidence in the first two years of life and a slight male predominance, whereas presentation of this neoplasm in older ages is extremely rare.

• sawsan ismail

This article presents a 54-year-old Syrian female who presented at our institution due to dysphagia, dyspnea, cervical swelling, and loss of appetite. Following clinical and radiological examinations, total thyroidectomy with lymph node dissection was performed. Microscopic examination revealed an infiltrative growth pattern of insular, trabecular, and solid formations of epithelial cells with scant eosinophilic cytoplasm, hyperchromatic nuclei, and bizarre mitotic figures with areas of necrosis. Subsequently, the final diagnosis was confirmed as a multifocal poorly differentiated thyroid carcinoma arising from a substernal goiter

• sawsan ismail

Atypical Teratoid/Rhabdoid Tumor (AT/RT) is a rare aggressive neoplasm that mainly affects the pediatric population with a peak incidence in the first two years of life and a slight male predominance, whereas presentation of this neoplasm in older ages is extremely rare

• sawsan ismail

Background

High-risk non-muscle-invasive bladder cancer (HR-NMIBC) presents a challenge to many physicians due to its ability to resist Bacillus Calmette–Guérin (BCG) intravesical therapy and the substantial rate of progression into muscle-invasive bladder cancer (MIBC). Patients who are BCG-unresponsive have worse prognosis and thus require further management including radical cystectomy (RC), which significantly impacts quality of life. Moreover, the ongoing worldwide shortage of BCG warrants the need for policies that prioritize drug use and utilize alternative treatment strategies. Hence, there is a significant unmet need for bladder preserving therapy in this subset of patients.

• Zein Alabdin Hannouneh
• Amjad Hijazi
• Alaa Aldeen Alsaleem
• Siwan Hami
• Abd Alfattah Abbas

• Hussain Maihoub Salman

• Hussain Maihoub Salman

Direct Current (DC) is widely used in electrotherapy for disease treatment, with typical studies on the effect of DC on disease factors in the blood. The objective of this work was to study the effects of DC on human blood, and to determine the intensity of DC that safely flows through blood, and to know which components of blood are most affected by DC. The effects on the counts or levels of main blood components [Red Blood Cells (RBCs), White Blood Cells (WBCs), Platelets (PLTs), Hemoglobin (Hb), and Hematocrit (Hem)] were considered. DC intensities from 1 to 10 mA were passed through blood samples of ten healthy persons for periods of up to one hour. A blood test (blood count with white blood cell differential) was carried out before DC flow and after 5, 10, 15, 30, 45, and 60 minutes of treatment.

• Joumana Mahmoud Diab
• Ahmad Ahmad
• Abd Alfattah Abbas
• Ward khalifa Abo-Amsha

Sickle cell anemia SCA is considered a major health problem in Syria

• Zainab M. Ismail
• Rana Ahmad
• Fahd F. Hasan
• Zbeida B. Nassif

The main role of thyroid hormones is to maintain normal brain growth during a critical period of life. Congenital hypothyroidism (CH) is one of the most common cause of mental retardation

• Rana Ahmad
• Haider A. Al-Barry

Sickle cell anemia (SCA) is a chronic hemolytic disorder. It is considered as a major health problem in Syria. The risk of this disease varies among patients worldwide. Fetal hemoglobin (HbF) decreases the severity of SCA by inhibiting the polymerization of sickle hemoglobin (HbS). The aim of this study is to determine the HbF levels in SCA patients. Blood samples were collected from 175 SCA patients. The level of HbF was more than 10%, High level of HbF in 126/175 Patients. The mean of HbF levels was 24.75± 18.8%, and varied according to age, gender, SCD complications. The relation between HbF and SCA complications is still unclear, therefore, more studies were recommended.

• Haider A. Al-Barry
• Salwa I. Salloum
• Rana Ahmad

War provides ideal grounds for the outbreak of infectious diseases, and the Syrian war is not an exception to this rule. Following the civil crisis, Syria and refugee camps of neighboring countries witnessed an outbreak of leishmaniasis.

• Rafea Shaban
• Souha S. Kanj
• Alexey Youssef
• Zuheir Alshehabi
• Saeed El Zein
• Reem Mohsen Harfoush

Chronic prostatitis is the first among men's genital diseases, affecting men at the age of 25-40 years. Many researchers have studied the various immune system episodes in chronic Prostatitis patients

• Ayman Hussien Harfoush

Ovarian cancer is the most lethal gynecologic malignancy, nearly 80% of patients are diagnosed at advanced stage disease (III/IV). Different risk factors are associated with ovarian cancer Obesity, High fat diet, Hormone replacement therapy, and most importantly a family history of breast/ovarian cancer and/or colon cancer. Close relative with ovarian cancer increases a woman’s risk of developing ovarian cancer by ~3 times

• Sami Azrak

The amplification of human epidermal growth factor receptor 2 (HER2) gene in breast cancer identifies patients eligible for Trastuzumab therapy. immunohistochemistry (IHC) and/or fluorescent in situ hybridization (FISH) are the only FDA approved techniques for evaluating HER2 status. However, Interobserver variability is still a dilemma

• Sami Azrak
• Batool Alassar
• Thaer Khoury

Dynamics of sperm motility (sperm velocity, percentage of motility and flagellar beat frequency) and monthly variations of semen characteristics (semen volume and osmolality and sperm concentration and motility) were studied. These criteria were used in the embryology laboratory and reproductive biology in the city of Lattakia, Syria, This study showed that sperm velocity, percentage of motility and beat frequency significantly and rapidly decreased after the activation of sperm motility. To study the dynamics of sperm motility parameters, twenty permeating males were randomly selected and electronically tagged to study the variations of semen characteristics. Specially we focused on the relationship between segmentation failure in cases treated with In Vitro Fertilization (IVF) to define the characteristics using the Computer Assisted Sperm Analysis (CASA).

• Hassan Hasan
• Mohammad Habib Harfoush

The relationship between blood group type and the incidence of diseases has been studied.1 Some studies reported possible link between blood group O and stomach cancer,2-5 bladder cancer in group A carriers6 and hepatocellular carcinoma in non-group (O) carriers

• Ibrahim Ali Suliman

This paper presents a new method for separating Rhenium, Molybdenum, Vanadium and Tungsten ions on a thin layer of Perlite using the thin layer -electro-chromatography method. This method is based on the combination between chromatographic forces and electric forces by applying different voltages on the separation plate for different times using several electrolytes as different mobile phase concentrations, at different applying field duarations on the process. This method also shows the possibility of using Perlite as a thin layer in this kind of separation process, which can apply in the separation of other types of biochemistry and inorganic ions This relatively simple method is cost effective.

• Yaseen Ahmad Moalla
• Ibrahim Jabbour