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Toripalimab in Esophageal Cancer: A Systematic Review and Meta-Analysis

Following PRISMA 2020 guidelines, we conducted a systematic review and meta-analysis, searching PubMed, Embase, Scopus, ScienceDirect, and Google Scholar up to January 2025. Eligible studies evaluated Toripalimab in esophageal cancer, including randomized controlled trials and non-randomized controlled trials. Primary outcomes included overall survival (OS), progression-free survival (PFS), and objective response rate (ORR), while safety outcomes assessed treatment-related adverse events. Data were synthesized using random-effects models, with heterogeneity evaluated via Cochrane’s Q and I2 statistics.

Journal of Gastrointestinal Cancer

Mid-to-Long-term Clinical Outcomes of Ankle Arthroscopy on the Treatment of Chronic Ankle Conditions: Systematic Review and Meta-analysis

In total, 47 studies were included, encompassing 2,653 patients. Arthroscopic surgery resulted in a significant decrease in pain intensity for osteochondral lesions (MD = −4.49, P = .002) and ankle osteoarthritis (MD = −2.88, P = .034). Functional improvements were observed with notable success rates: 92.5% (soft tissue impingement), 87.5% (ankle synovitis), 73.2% (osteochondral lesions), 71.53% (bony impingement), and 54.7% (ankle osteoarthritis).

Foot and Ankle Specialist

Vision for the Future Hospital in Response to the Challenges of the Current Reali

Healthcare is confronted by enormous challenges such as financial
and demographic changes, exponential technological progress,
an increasing incidence of chronically ill patients with changing
needs for care.
To meet these challenges and the associated changing of social
needs and expectations, our healthcare is constantly evolving.
When there is an acceleration or fault line in the variable care
needs, it is insufficient to make adjustments only to the current
models but also there is a need for a fundamental reform. If
health care is to be affordable, high-quality and accessible in
the future too, then the use of scarce resources is crucial. This
research focuses on the hospital of the future and the future of
the hospital within a larger healthcare system and consists of two
large sections.

Journal of Civil Engineering Research & Technology

Effect of direct electric current on human blood count

Direct Current (DC) is widely used in electrotherapy for disease treatment, with typical studies on the effect of DC on disease factors in the blood. The objective of this work was to study the effects of DC on human blood, and to determine the intensity of DC that safely flows through blood, and to know which components of blood are most affected by DC. The effects on the counts or levels of main blood components [Red Blood Cells (RBCs), White Blood Cells (WBCs), Platelets (PLTs), Hemoglobin (Hb), and Hematocrit (Hem)] were considered. DC intensities from 1 to 10 mA were passed through blood samples of ten healthy persons for periods of up to one hour. A blood test (blood count with white blood cell differential) was carried out before DC flow and after 5, 10, 15, 30, 45, and 60 minutes of treatment.

Songklanakarin J. Sci. Technol

Neonatal Screening for Congenital Hypothyroidism at Obstetrics and Pediatrics Hospital in Lattakia, Syria

The main role of thyroid hormones is to maintain normal brain growth during a critical period of life. Congenital hypothyroidism (CH) is one of the most common cause of mental retardation

Research Journal of Pharmacy and Technology

Fetal Hemoglobin (HbF) levels in Sickle cell anemia patients in Lattakia, Syria

Sickle cell anemia (SCA) is a chronic hemolytic disorder. It is considered as a major health problem in Syria. The risk of this disease varies among patients worldwide. Fetal hemoglobin (HbF) decreases the severity of SCA by inhibiting the polymerization of sickle hemoglobin (HbS). The aim of this study is to determine the HbF levels in SCA patients. Blood samples were collected from 175 SCA patients. The level of HbF was more than 10%, High level of HbF in 126/175 Patients. The mean of HbF levels was 24.75± 18.8%, and varied according to age, gender, SCD complications. The relation between HbF and SCA complications is still unclear, therefore, more studies were recommended.

Research Journal of Pharmacy and Technology

Visceral and Cutaneous Leishmaniases in a City in Syria and the Effects of the Syrian Conflict

War provides ideal grounds for the outbreak of infectious diseases, and the Syrian war is not an exception to this rule. Following the civil crisis, Syria and refugee camps of neighboring countries witnessed an outbreak of leishmaniasis.

The American Journal of Tropical Medicine and Hygiene - Current Issue

EVALUATION OF THE USING OF AUTOHEMOTHERAPY IN THE TREATMENT OF CHRONIC PROSTATITIS BY REBUCK'S SKIN WINDOW TECHNIQUE

Chronic prostatitis is the first among men's genital diseases, affecting men at the age of 25-40 years. Many researchers have studied the various immune system episodes in chronic Prostatitis patients

International Journal of Dental and Health Sciences

Hereditary Ovarian Cancer and Germline Mutations: Review Article

Ovarian cancer is the most lethal gynecologic malignancy, nearly 80% of patients are diagnosed at advanced stage disease (III/IV). Different risk factors are associated with ovarian cancer Obesity, High fat diet, Hormone replacement therapy, and most importantly a family history of breast/ovarian cancer and/or colon cancer. Close relative with ovarian cancer increases a woman’s risk of developing ovarian cancer by ~3 times

Journal of Genetics and Genetic Engineering

The Detection of HER2 Gene Amplification in Breast Cancer by upQMPSF

The amplification of human epidermal growth factor receptor 2 (HER2) gene in breast cancer identifies patients eligible for Trastuzumab therapy. immunohistochemistry (IHC) and/or fluorescent in situ hybridization (FISH) are the only FDA approved techniques for evaluating HER2 status. However, Interobserver variability is still a dilemma

Journal of Genetics and Genetic Engineering

The relationship between segmentation failure and spermatozoa motility characteristics

Dynamics of sperm motility (sperm velocity, percentage of motility and flagellar beat frequency) and monthly variations of semen characteristics (semen volume and osmolality and sperm concentration and motility) were studied. These criteria were used in the embryology laboratory and reproductive biology in the city of Lattakia, Syria, This study showed that sperm velocity, percentage of motility and beat frequency significantly and rapidly decreased after the activation of sperm motility. To study the dynamics of sperm motility parameters, twenty permeating males were randomly selected and electronically tagged to study the variations of semen characteristics. Specially we focused on the relationship between segmentation failure in cases treated with In Vitro Fertilization (IVF) to define the characteristics using the Computer Assisted Sperm Analysis (CASA).

American Journal of Biomedical and Life Sciences

Relationship between ABO Blood Group and End-stage Renal Disease in Latakia, Syria

The relationship between blood group type and the incidence of diseases has been studied.1 Some studies reported possible link between blood group O and stomach cancer,2-5 bladder cancer in group A carriers6 and hepatocellular carcinoma in non-group (O) carriers

Saudi Journal of Kidney Diseases and Transplantation

Separating a mixture of Re (VII), Mo (VI), V (V) and W (VI) ions using the thin layer electro-chromatography method on a thin layer of perlite

This paper presents a new method for separating Rhenium, Molybdenum, Vanadium and Tungsten ions on a thin layer of Perlite using the thin layer -electro-chromatography method. This method is based on the combination between chromatographic forces and electric forces by applying different voltages on the separation plate for different times using several electrolytes as different mobile phase concentrations, at different applying field duarations on the process. This method also shows the possibility of using Perlite as a thin layer in this kind of separation process, which can apply in the separation of other types of biochemistry and inorganic ions This relatively simple method is cost effective.

Science Journal of Analytical Chemistry