SYNTHESIS OF 3-CARBOXYLIC DERVATIVES OF 1, 5- BENZOTHIAZEPINES

• Publish Date: 2018-01-01

Research Abstract:

A series of 3-carboxylic derivatives of disubstituted 1,5-benzodiazepines (5–9) was synthesized by hetero-cyclisation from 1,2-diaminobenzene (1) with dibenzoylmethane (2) followed by bromination on position 3 and by introduction of the carboxylic group or introduction of the malonic moiety. Reduction of the hetero-cycle gave the perhydro derivative diethyl (2,4-diphenyl-1,2,4,5-tetrahydro-3H-1,5-benzodiazepin-3-yl)malonate (9).

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