Molecular Classification Of The Breast Cancer
- Publish Date:
- 03/04/2021
Breast cancer is very frequent and has many social and psychological implications. For the therapeutic and predictive approach to these tumors, the molecular classification of breast malignancies into five groups was based on (IHC) staining ER, PR, Her2 / neu, Ki-67.
100 samples were selected from Tishreen University Hospital patients with ductal or lobular invasive carcinoma to study molecular classification by (IHC) method during the period 2017-2018. We clarified the relationship of molecular classification with different prognostic factors: age, tumor size, patterns, histological degree, and status of Axillary lymph node, using a statistical analysis - cross sectional study using the (SPSS) program. The results were 77 ductal carcinomas, Luminal A (24.7%), Luminal B (24.7%), HER2-enriched (16.9%), Triple-negative (26%) and Normal like (7.8%). It found 23 lobular carcinomas, Luminal A (17.4%), Luminal B (47.8%), HER2-enriched (4.3%), Triple-negative (7.8%) and Normal like (21.7%). We note the arrangement of the molecular patterns starting from the worst alarm according to the studied prognostic factors as follows: Luminal B, Triple-Negative or basal like, luminal A, HER2-enriched, normal like.
Conclusion: Molecular classification of breast cancers using immunohistochemical staining (IHC) (ER, PR, Her2 / neu, Ki-67) is useful in developing treatment strategies and determining prognosis.
