Innovative Microencapsulation of Polymyxin B for Enhanced Antimicrobial Efficacy via Coated Spray Drying

• Publish Date: 2024-10-19

Research Abstract:

This study aims to develop an innovative microencapsulation
method for coated Polymyxin B, utilizing various
polysaccharides such as hydroxypropyl β-cyclodextrin, alginate, and
chitosan, implemented through a three-fluid nozzle (3FN) spray
drying process. High-performance liquid chromatography (HPLC)
analysis revealed that formulations with a high ratio of sugar cage,
hydroxypropyl β-cyclodextrin (HPβCD), and sodium alginate
(coded as ALGHCDHPL
PM) resulted in a notable 16-fold increase in
Polymyxin B recovery compared to chitosan microparticles.
Morphological assessments using fluorescence labeling confirmed
successful microparticle formation with core/shell structures.

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