An Experimental Study Involving Professor Dr. Abdul Karim Khalil and Student Mohamed Ali Ali from Al Andalus University for Medical Sciences
- Publish Date:
- 06/09/2025
Study Objective:
This experiment seeks to determine the effect of using a gel containing 1% Simvastatin when applied topically on the bone regeneration process in the mandible, using an experimental rat model.
Methodology:
Male Wistar rats were selected. The study began with the surgical removal of the testes, which leads to a decrease in testosterone levels, consequently reducing osteoblast activity and increasing osteoclast activity—a condition resembling an osteoporotic environment.
Subsequently, two adjacent bone defects were created in the mandible of each rat.
One defect was treated with 1% Simvastatin gel, while the other was left untreated to serve as a control group.
Histological evaluation of the bone healing process was conducted at different time intervals (after 30, 60, and 90 days) using the international Allen’s Scoring System to determine the stages of bone healing.
Results:
Histological examinations showed a significant improvement in early bone repair in the Simvastatin-treated groups at days 30 and 60 compared to the untreated group (P < 0.05).
By day 90, no statistically significant differences were recorded between the two groups, indicating that the effect of Simvastatin is concentrated in the early stages of healing.
Scientific Significance:
These results demonstrate that Simvastatin could be a promising adjunctive option in bone regeneration protocols during maxillofacial surgeries. However, generalizing these findings requires additional studies with larger sample sizes and more advanced analytical techniques to ensure reliability and safe, effective clinical applicability.
Publication:
The research was published in the Annals of Medicine and Surgery under the title:
"The local application of a 1% simvastatin gel improves bone regeneration in osteoporotic mandibular defects: a rat model study"
Research Team as listed:
- Prof. Dr. Abdul Karim Khalil – Consultant and Professor of Oral and Maxillofacial Surgery, Latakia University (Supervisor)
- Prof. Dr. Ali Dawood – Head of the Pathology and Histology Department, Latakia University Hospital (Supervisor)
- Dr. Karam Ahmed – PhD in Oral and Maxillofacial Surgery, Latakia University Hospital (First Researcher)
- Mohamed Ali – Student at the Faculty of Dentistry, Al Andalus University for Medical Sciences (Corresponding Researcher)
Suleiman Mohamed – Student at the Faculty of Dentistry, UMFST, Targu Mures, Romania
