Aggressive primary uterine non-Hodgkin’s lymphoma presenting as acute kidney injury: a case report

• Publish Date: 2025-05-24

Research Abstract:

Primary malignant lymphoma of the cervix is an extremely rare condition, accounting for only 0.008% of all cervical tumors and 2% of female extranodal lymphomas. The most common histological subtype is diffuse large B-cell lymphoma. This malignancy is often asymptomatic in its early stages, but advanced cases may include systemic symptoms, pelvic discomfort, and vaginal bleeding. Diagnosis is challenging due to its nonspecific clinical presentation and similarity to other gynecological conditions. Imaging and immunohistochemistry play essential roles in diagnosis and staging. Treatment typically involves chemotherapy, with the standard CHOP regimen for Non-Hodgkin’s lymphoma being the main treatment in most cases. To the best of our knowledge, this is the first case in the literature to describe acute kidney injury associated with the already rare entity of primary female genital tract lymphoma.

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