Assistant Professor
D. Mustafa Bish
- Faculty Member
Microbiological and Analytical Evaluation of Semi-Solid Formulations of Do xycycline Hy clate under Acceler ated Stability Conditions
Baghdad Science Journal1 - September - 2025
Doxycycline Hyclate (DOX) is a broad-spectrum antibiotic that belongs to the tetracycline family. It has been widely used in the treatment of several inflammatory diseases, and is considered the first-line therapy in the management of moderate to severe cases of acne. In this research, Doxycycline was formulated in four semi-solid formulations (F1and F2 as Gels, F3 and F4 as ointments), then these formulations were subjected to accelerated stability conditions for three months. The formulations were evaluated using microbiological and analytical methods after one and three months. Agar well diffusion method was used as a microbiological method to screen the antibacterial activity of semi-solid formulations against two types of bacteria, Staphylococcus Aureus and Pseudomonas Aeruginosa. HPLC was used as an analytical method for the quantitative and qualitative determination of these formulations.
Download FileQUALITY ANALYSIS OF DIFFERENT MARKETED BRANDS OF ATENOLOL (50 MG) TABLETS AVAILABLE IN SYRIA AND COMPARING WITH THE REFERENCE DRUG
World Journal of Pharmaceutical Research13 - February - 2018
There are numerous generics of atenolol tablets available in Syria. The purpose of current study is to assess the physicochemical characters of four brands(A, B, C, D) of atenolol(50mg) tablets advertised in Syria and comparing these properties with reference drug(E). The physicochemical equivalence of brands of atenolol tablets were evaluated through performing hardness, friability, weight variation, content uniformity, and dissolution rate tests. The highest values of hardness are founded in tablets brand A while other brands are nearest in hardness to reference drug.
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