مدرس سابق
D. Samer Al-Hosha
- مدرس سابق
Analysis of Prasugrel by Chromatography - Review
International Journal of Pharmaceutical Sciences Review and Research9 - March - 2017
Prasugrel, being a potent platelet aggregation inhibitor, is used widely around the world to reduce cardiovascular risks in patients with stroke, myocardial infarction, and atherosclerosis. The aim of this review firstly to focus on a comprehensive update of chromatography determination of Prasugrel and its metabolites in human plasma, and in pharmaceutical preparations. It has been described using TLC, HPLC/MS, RP-HPLC, and UV methods. Secondly to localize the chromatographic conditions for separation and quantification. This review provides detailed information on separation conditions for Prasugrel alone, with Aspirin, and in the presence of its related compounds
Download FileCanagliflozin, being a Sodium Glucose co-Transporter type 2 (SGLT2) Inhibitor, as a new class for treatment of Type 2 diabetes mellitus, offer a novel mechanism of action, which has been recently approved by USFDA for use in type 2 diabetes mellitus, either alone or in combination with other oral hypoglycaemic agents and insulin. The aim of this review firstly to focus on a comprehensive update of chromatography determination of Canagliflozin in bulk and in pharmaceutical preparations, In which has been described using TLC, HPLC/MS, RP-HPLC and UV methods. Secondly to localize the chromatographic conditions for separation and quantification. This review provides detailed information on separation conditions for Canagliflozin alone, with Metformin and in the presence of its degradation products.
Download FileIdentification and Characterization of Prasugrel Degradation Products by GC/MS, FTIR and 1H NMR
Asian Journal of Pharmaceutical Analysis8 - March - 2017
The objective of the present work was to separate, identify and characterize the degradation products of Prasugrel hydrochloride under hydrolytic and oxidative stress conditions according to the International Conference on Harmonization (ICH) guideline Q1A (R2).
Download FileDevelopment of Rapid, Simple and Stability-Indicating Method for Determination of Azithromycin Using RP-HPLC
Asian Journal of Pharmaceutical Analysis8 - March - 2017
An accurate, sensitive, precise and stability indicating (in accordance with ICH guidelines) reversed phase high performance liquid chromatographic (RP-HPLC) method of analysis of Azithromycin was developed and validated.
Perindopril erbumine is an antihypertensive, which belongs to the category of angiotensin-converting enzyme inhibitors (ACE inhibitors) that inhibit the conversion of angiotensin I to angiotensin II. The aim of this review is to focus on a comprehensive update of analytical methods for determination of Perindopril and its metabolites in human plasma and in pharmaceutical preparations. It has been described using TLC, RP-HPLC, GC, Mass and UV methods. This review provides detailed information on separation conditions for perindopril alone, perindopril in presence of its degradation products or with its combinations.
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