مدرس سابق
D. Wissam Al-Zamm
- مدرس سابق
Alginate-pomegranate peels’ polyphenols beads: effects of formulation parameters on loading efficiency
Brazilian Journal of Pharmaceutical Sciences / 1 - December - 2014
Calcium alginate beads containing pomegranate peels’ polyphenol extract were encapsulated by ionic gelation method. The effects of various formulation factors (sodium alginate concentration, calcium chloride concentration, calcium chloride exposure time, gelling bath time maintaining, and extract concentration) on the efficiency of extract loading were investigated. The formulation containing an extract of 1 g pomegranate peels in 100 mL distilled water encapsulated with 3 % of sodium alginate cured in 0.05 M calcium chloride for 20 minutes and kept in a gelling bath for 15 minutes was chosen as the best formula regarding the loading efficiency. These optimized conditions allowed the encapsulation of 43.90% of total extracted polyphenols and 46.34 % of total extracted proanthocyanidins.
Download FileVITAMIN D DEFICIENCY AND DEPRESSIVE DISORDERS: REVIEW STUDY OF PROBABLE RELATIONSHIP
International Journal of Pharmacy and Pharmaceutical Sciences / 1 - January - 2016
Vitamin D deficiency is evident in many parts of the world, even in the sunnier regions, for a variety of reasons. Recently, vitamin D has been reported in many scientific researchers as an important factor that may have significant health benefits in the prevention and the treatment of many chronic illnesses such as depression. According to the Global Burden of Disease Study, depression is one of the world's leading causes of disability and affects 350 million people in all communities across the world.
Download FileOptimization of extraction conditions for the recovery of phenolic compounds and antioxidants from Syrian olive leaves
Journal of Pharmacognosy and Phytochemistry / 1 - October - 2016
In this study the effect of extraction conditions, solvent (type, composition), time and temperature, on the amount of phenolic compounds extracted from olive leaves obtained from Safita /Syria was investigated and the radical scavenging activity of these extracts was evaluated. The total phenolic content and the radical scavenging activity of olive leaves extracts were determined by Folin-Ciocalteu reagent and scavenging of DPPH (2,2- diphenyl-1-picrylhydrazyl) radical, respectively. It was found that concentration of solvents (40% ethanol, 40% methanol, 80% acetone, and 6:2: acetone: ethanol: water) gave the highest total phenolic content and possess strong activity against the DPPH radicals (IC50 18.92, 25.01, 33.15, 37.19 μg Gallic acid /ml), respectively.
Download FileOLIVE LEAVES HERBAL TEA EFFECT IN TYPE 2 DIABETIC PATIENTS WITH PREHYPERTENSION
EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH / 8 - March - 2017
Olive tree leaves have been widely used in traditional medicine for its antioxidant, antihypertensive, hypoglycemic, hypocholesterolemic and cardioprotective activity. A clinical study was conducted to evaluate the antihypertensive effect of olive leaves herbal tea (50 g of dried and ground leaves in 250 ml of warm water/twice daily for 28 weeks) in type 2 diabetic patients (n=31, 13 women and 18 men) diagnosed with prehypertension.
Download FileExtracting and studying the antioxidant capacity of polyphenols in dry linden leaves (Tilia cordata)
Journal of Pharmacognosy and Phytochemistry / 18 - April - 2017
Medicinal potentials of the flowers and leaves of Tilia species (Linden) make them valuable plants in pharmacognosy researches. The present study is an attempt to investigate the optimal conditions for the extraction of phenolic compounds from Tilia cordata leaves harvested from the coastal mountains located at the west of Syria.
Arginine enzymatic deprivation and diet restriction for cancer treatment
Brazilian Journal of Pharmaceutical Sciences / 15 - May - 2017
Recent findings in amino acid metabolism and the differences between normal, healthy cells and neoplastic cells have revealed that targeting single amino acid metabolic enzymes in cancer therapy is a promising strategy for the development of novel therapeutic agents. Arginine is derived from dietary protein intake, body protein breakdown, or endogenous de novo arginine production and several studies have revealed disturbances in its synthesis and metabolism which could enhance or inhibit tumor cell growth. Consequently, there has been an increased interest in the arginine-depleting enzymes and dietary deprivation of arginine and its precursors as a potential antineoplastic therapy. This review outlines the most recent advances in targeting arginine metabolic pathways in cancer therapy and the different chemo- and radio-therapeutic approaches to be co-applied.
In vitro Evaluation of Helicobacter pylori and Ureases Inhibition Activity of Syrian Honey Samples
Current Enzyme Inhibition / 29 - October - 2017
considering that Helicobacter pylori, a bacterium associated with a number of important upper gastrointestinal conditions, not always can be effectively eradicated by the traditional approaches, there is an interest in alternative therapies.
WOUND DRESSINGS UPLOADED WITH MYRTLE BERRIES EXTRACT AND NIGELLA SATIVA HONEY
Universal Journal of Pharmaceutical Research / 22 - September - 2018
Wound dressings are frequently developed by introducing new products to target different aspects of the wound healing process. Many medicated dressings incorporated with natural extracts and chemicals have been developed. Chronic wounds could be invaded by many bacteria and Pseudomonas aeruginosa and Staphylococcus aureusare the most common
OPTIMIZATION OF DIFFERENT PARAMETERS FOR THE EXTRACTION OF POLYPHENOLS AND PROANTHOCYANIDINS FROM PISTACIA VERA HULLS
International Journal of Pharmacy and Pharmaceutical Sciences / 1 - December - 2019
Objective: Pistachio (Pistacia vera L.) hull are usually discarded as waste, which can lead to environmental pollution even a significant portion of polyphenols are often present in high concentrations in the outer parts of fruits. In this way, using a pistachio hull as a source of bioactive compounds will increase the value of pistachio production and offer valorization for a useless by-product. Methods: Different ethanol concentrations (5, 10, 25, 50, 75 and 95 %) were investigated and the extraction efficiency at extraction temperature from 20 to 90 °C and extraction times from 5 to 45 min was studied. The extraction yield of total polyphenols and proanthocyanidins from the pistachio hull and the antioxidant activity of the extract were evaluated.
Structured lipids: methods of production, commercial products and nutraceutical characteristics
Journal of Nutrition and Internal Medicine / 3 - September - 2015
Structured lipids (SLs) are generally defined as triacylglycerols (TAGs) that have been modified to change the fatty acid composition and/or their positional distribution in glycerol molecules by chemical and/or enzymatic reactions and/or by genetic engineering processes.
Impact of Phytochemicals and Dietary Patterns on Epigenome and Cancer
Nutrition and Cancer / 8 - March - 2017
Cancer remains one of the leading causes of death around the world. Initially it is recognized as a genetic disease, but now it is known to involve epigenetic abnormalities along with genetic alterations. Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but play an important role in the control of gene expression. It includes changes in DNA methylation, histone modifications, and RNA interference. Although it is heritable, environmental factors such as diet could directly influence epigenetic mechanisms in humans
Effect of Alginate and Chitosan Edible Coating Enriched with Olive Leaves Extract on the Shelf Life of Sweet Cherries (Prunus avium L.)
Journal of Food Quality / 24 - July - 2019
Edible film coatings are widely used as a protective barrier for the reduction of transpiration and respiration, therefore reducing the ripening process in fruits and vegetables and improving their quality. The influence of chitosan 1% and alginate 3% enriched with olive leaves extract (OLE) on the quality of sweet cherries was studied. Overall, the ripening process and the increase in anthocyanins were found to be delayed with the use of coating particularly those composed of chitosan in combination with OLE
Download FileCurrent Trends on Seaweeds: Looking at Chemical Composition, Phytopharmacology, and Cosmetic Applications
Molecules / 1 - June - 2020
Seaweeds have received huge interest in recent years given their promising potentialities. Their antioxidant, anti-inflammatory, antitumor, hypolipemic, and anticoagulant effects are among the most renowned and studied bioactivities so far, and these effects have been increasingly associated with their content and richness in both primary and secondary metabolites
Download FileEx Vivo Study of Laban's Role in Decreasing Hemolysis Crisis in G6PD-Deficient Patients
Journal of Nutrition and Metabolism / 21 - December - 2020
In spite of the vast nutritional and environmental benefits provided by fava bean (Vicia faba), the ingestion of vicine/convicine provokes an acute hemolytic anemia called favism in individuals with a glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Download FileParameters Influencing Phenolic compounds extraction from Pistacia palaestina fruits during different stages of Maturity
Research Journal of Pharmacy and Technology / 1 - June - 2020
Pistacia species are used in food industry and as medicinal for the remedy for various diseases
Download FileMethods of Spectroscopy for Selenium Determination: A Review
Research Journal of Pharmacy and Technology / 1 - June - 2020
Selenium (Se) is cumulative nonmetallic element that occurs naturally in a range of oxidation states as volatile species or analogues of organic sulphur compounds
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