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ABSTRACT


Vildagliptin, a dipeptidyl peptidase-4 inhibitor, is one of the potent oral antidiabetic agent. vildagliptin is considered as new drug.
There has been no monograph for it in pharmacopeia. So, the objective of the present work was to develop a new simple, accurate and precise spectrophotometer method as per ICH guideline for estimation of Vildagliptin in bulk. and Vildaglptin has absorbance at the wavelength of maximum λmax = 202.5 in 0.5 M HCl, Proposed method was precise with RSD less than 2%. Linearity test was approved within range of 10-40 μg/ml for with correlation coefficient (R2) of 0.999. Accuracy was 100.17%. LOD and LOQ were 0.055 μg/ml and 0.166 μg/ml, respectively. The spike recovery of vildagliptin in tablet was 99.96%, so this method has been successfully applied on national pharmaceutical product.

 

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