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Introduction: Pseudomonas aeruginosa is an opportunistic pathogen leading to severe, acute and chronic infections in burn patients. In the process of wound healing, a significant delay in the closure of excisional wound sites is due to the bacterial skin infection, so anti-infection is important in wound healing. Objective: abuse of antibiotics leads to the development of multi drug resistance of P. aeruginosa strains which require a rapid intervention to find a solution focusing on new natural antibacterial pathways. Punica granatum (pomegranate) has emerged as a medicinal plant with potential antimicrobial activity. The present study was planned to evaluate this activity against P. aeruginosa collected from burn wound cultures. Methods: aqueous extract of sweet pomegranate peels from Safita, a mountainous region west of Syria was prepared. Minimum inhibitory concentration (MIC) and antivirulence efficacy were determined for the -prepared extract. Results: MIC was 1.4 mg/ml and bacterial gelatinase and lecithinase activities were reduced by 40.28±2.35% and 53.84±4.89%, respectively. Conclusion: the extracts from pomegranate fruit peel possess strong antimicrobial and antivirulence activities against P. aeruginosa. Therefore this plant could be an important source of new antimicrobial compounds.

Keywords: Pseudomonas aeruginosa; pomegranate peels; MIC; gelatinase; lecithinase