Associated with Estrogens
(See WARNINGS regarding induction of neoplasia, adverse effects on the fetus, increased incidence of gallbladder disease, and adverse effects similar to those of oral contraceptives, including thromboembolism). The following additional adverse reactions have been reported with estrogenic therapy, including oral contraceptives:
Breakthrough bleeding, spotting, change in menstrual flow.
Amenorrhea during and after treatment.
Increase in size of uterine fibromyomata.
Change in cervical erosion and in degree of cervical secretion.
Tenderness, enlargement, secretion.
Abdominal cramps, bloating.
Chloasma or melasma which may persist when drug is discontinued.
Loss of scalp hair.
Steepening of corneal curvature.
Intolerance to contact lenses.
Headache, migraine, dizziness.
Increase or decrease in weight.
Reduced carbohydrate tolerance.
Aggravation of porphyria.
Changes in libido.
Associated with Methyltestosterone
Endocrine And Urogenital
- Female: The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued. When administered to a pregnant woman androgens cause virilization of external genitalia of the female fetus.
- Skin and Appendages: Hirsutism, male pattern of baldness, and acne.
- Fluid and Electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
- Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function test, rarely hepatocellular neoplasms, and peliosis hepatis (see WARNINGS).
- Hematologic: Suppression of clotting factors, II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
- Nervous System: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
- Metabolic: Increased serum cholesterol.
- Miscellaneous: Inflammation and pain at site of intramuscular injection or subcutaneous implantation of testosterone containing pellets, stomatitis with buccal preparations, and rarely anaphylactoid reactions.