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Adverse reactions with the use of LUFYLLIN (dyphylline) have been infrequent, relatively mild, and rarely required reduction in dosage or withdrawal of therapy.

The following adverse reactions which have been reported with other xanthine bronchodilators, and which have most often been related to excessive drug plasma levels, should be considered as potential adverse effects when dyphylline is administered:

Gastrointestinal:   nausea, vomiting, epigastric pain, hematemesis, diarrhea.

Central nervous system:   headache, irritability, restlessness, insomnia, hyperexcitability, agitation, muscle twitching, generalized clonic and tonic convulsions.

Cardiovascular:   palpitation, tachycardia, extrasystoles, flushing, hypotension, circulatory failure, ventricular arrhythmias.

Respiratory:   tachypnea.

Renal:   albuminuria, gross and microscopic hematuria, diuresis.

Other:   hyperglycemia, inappropriate ADH syndrome.