The following adverse reactions have been observed, but there is not enough systematic collection of data to support an estimate of their frequency.
Anorexia, gastric irritation, nausea, vomiting, cramping, diarrhea, constipation, jaundice (intrahepatic cholestatic jaundice), pancreatitis, sialadenitis.
CENTRAL NERVOUS SYSTEM
Dizziness, vertigo, paresthesias, headache, xanthopsia.
Leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia.
Orthostatic hypotension (may be aggravated by alcohol, barbiturates, or narcotics).
Purpura, photosensitivity, rash, urticaria, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis, anaphylactic reactions.
Hyperglycemia, glycosuria, hyperuricemia, muscle spasm, weakness, restlessness, transient blurred vision.
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.