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The following adverse reactions have been observed, but there is not enough systematic collection of data to support an estimate of their frequency.

GASTROINTESTINAL SYSTEMS

Anorexia, gastric irritation, nausea, vomiting, cramping, diarrhea, constipation, jaundice (intrahepatic cholestatic jaundice), pancreatitis, sialadenitis.

CENTRAL NERVOUS SYSTEM

Dizziness, vertigo, paresthesias, headache, xanthopsia.

HEMATOLOGIC

Leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia.

CARDIOVASCULAR

Orthostatic hypotension (may be aggravated by alcohol, barbiturates, or narcotics).

DERMATOLOGIC HYPERSENSITIVITY

Purpura, photosensitivity, rash, urticaria, necrotizing angiitis (vasculitis, cutaneous vasculitis), fever, respiratory distress including pneumonitis, anaphylactic reactions.

OTHER

Hyperglycemia, glycosuria, hyperuricemia, muscle spasm, weakness, restlessness, transient blurred vision.

Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.