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The most frequent adverse reactions observed with the use of dinoprostone for abortion are related to its contractile effect on smooth muscle.

In the patients studied, approximately two-thirds experienced vomiting, one-half temperature elevations, two-fifths diarrhea, one-third some nausea, one-tenth headache, and one-tenth shivering and chills.

In addition, approximately one-tenth of the patients studied exhibited transient diastolic blood pressure decreases of greater than 20 mmHg.

Two cases of myocardial infarction following the use of dinoprostone have been reported in patients with a history of cardiovascular disease.

It is not known whether these events were related to the administration of dinoprostone.

Adverse effects in decreasing order of their frequency, observed with the use of dinoprostone, not all of which are clearly drug related include:

Vomiting Nocturnal leg cramps
Diarrhea Uterine rupture
Nausea Breast tenderness
Fever Blurred vision
Headache Coughing
Chills or shivering Rash
Backache Myalgia
Joint inflammation or Stiff neck
pain new or Dehydration
exacerbated Tremor
Flushing or hot flashes Paresthesia
Dizziness Hearing impairment
Arthralgia Urine retention
Vaginal pain Pharyngitis
Chest pain Laryngitis
Dyspnea Diaphoresis
Endometritis Eye pain
Syncope or fainting Wheezing
sensation Cardiac arrhythmia
Vaginitis or vulvitis Skin discoloration
Weakness Vaginismus
Muscular cramp or pain Tension
Tightness in chest