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Infrequently, high dosages of intranasal DDAVP have produced transient headache and nausea. Nasal congestion, rhinitis and flushing have also been reported occasionally along with mild abdominal cramps. These symptoms disappeared with reduction in dosage. Nosebleed, sore throat, cough and upper respiratory infections have also been reported.

The following table lists the percentage of patients having adverse experiences without regard to relationship to study drug from the pooled pivotal study data for nocturnal enuresis.

ADVERSE REACTION PLACEBO
(N=59)
DDAVP
20 mcg
(N=60)
DDAVP
40 mcg
(N=61)
  % % %
BODY AS A WHOLE
  Abdominal Pain 0 2 2
  Asthenia 0 0 2
  Chills 0 0 2
  Headache 0 2 5
NERVOUS SYSTEM
  Dizziness 0 0 3
RESPIRATORY SYSTEM
  Epistaxis 2 3 0
  Nostril Pain 0 2 0
  Rhinitis 2 8 3
DIGESTIVE SYSTEM
  Gastrointestinal Disorder 0 2 0
  Nausea 0 0 2
SPECIAL SENSES
  Conjunctivitis 0 2 0
  Edema Eyes 0 2 0
  Lachrymation Disorder 0 0 2

Post Marketing: There have been rare reports of hyponatremic convulsions associated with concomitant use with the following medications: oxybutinin and imipramine.

See WARNINGS for the possibility of water intoxication and hyponatremia.