The following serious adverse reactions to COUMADIN are discussed in greater detail in other sections of the labeling:
- Hemorrhage [see BOXED WARNING, WARNINGS AND PRECAUTIONS, and OVERDOSAGE]
- Necrosis of skin and other tissues [see WARNINGS AND PRECAUTIONS]
- Systemic atheroemboli and cholesterol microemboli [see WARNINGS AND PRECAUTIONS]
Other adverse reactions to COUMADIN include:
- Immune system disorders: hypersensitivity/allergic reactions (including urticaria and anaphylactic reactions)
- Vascular disorders: vasculitis
- Hepatobiliary disorders: hepatitis, elevated liver enzymes. Cholestatic hepatitis has been associated with concomitant administration of COUMADIN and ticlopidine.
- Gastrointestinal disorders: nausea, vomiting, diarrhea, taste perversion, abdominal pain, flatulence, bloating
- Skin disorders: rash, dermatitis (including bullous eruptions), pruritus, alopecia
- Respiratory disorders: tracheal or tracheobronchial calcification
- General disorders: chills