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In clinical trials, the following local adverse reactions were reported at some point during treatment.

Adverse Experience Males Females
Burning 64% 78%
Pain 50% 72%
Inflammation 71% 63%
Erosion 67% 67%
Itching 50% 65%

Reports of burning and pain were more frequent and of greater severity in women than in men.

Adverse effects reported in less than 5% of the patients included pain with intercourse, insomnia, tingling, bleeding, tenderness, chafing, malodor, dizziness, scarring, vesicle formation, crusting edema, dryness/peeling, foreskin irretraction, hematuria, vomiting and ulceration.