The most common adverse reaction in selected case series is transient flank pain which occurs in most patients. Additional common reactions include urothelial ulceration and/or edema (13%) or fever (20% but up to 40% in some case series). Other adverse reactions which occur in 1-10% of cases include: urinary tract infection, back pain, dysuria, transient hematuria, nausea, hypermagnesemia, hyperphosphatemia, elevated serum creatinine, candidiasis, and bladder irritability. Adverse reactions which occur in less than 1% of patients include: septicemia, ileus, vomiting, and thrombophlebitis. Death from sepsis has been reported.