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As with other plasma preparations, reactions manifested by fever, chills or indications of protein sensitivity may be observed with the administration of Autoplex® T, Anti-Inhibitor Coagulant Complex, Heat Treated. Signs and/or symptoms of high prekallikrein activity, such as changes in blood pressure or pulse rate may also be observed. It is advisable that appropriate medications be available for the treatment of acute allergic reactions or acute vasoactive reactions, should they occur.

A rate of infusion that is too rapid may cause headache, flushing, and changes in pulse rate and blood pressure. In such instances, stopping the infusion allows the symptoms to disappear promptly. With all but the most reactive individuals, infusion may be resumed at a slower rate.