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Yohimbine readily penetrates the CNS and produces a complex pattern of responses in lower doses than required to produce peripheral (alpha)-adrenergic blockage. These include anti-diuresis, a general picture of central excitation including elevated blood pressure and heart rate, increased motor activity, irritability and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug. 1,2 Also dizziness, headache, and skin flushing have been reported. 1,3