AMICAR (aminocaproic acid) is generally well tolerated. The following adverse experiences have been reported:
Edema, headache, malaise.
Allergic and anaphylactoid reactions, anaphylaxis.
Bradycardia, hypotension, peripheral ischemia, thrombosis.
Abdominal pain, diarrhea, nausea, vomiting.
Agranulocytosis, coagulation disorder, leukopenia, thrombocytopenia.
CPK increased, muscle weakness, myalgia, myopathy (see WARNINGS), myositis, rhabdomyolysis.
Confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope.
Dyspnea, nasal congestion, pulmonary embolism.
Tinnitus, vision decreased, watery eyes.
BUN increased, renal failure. There have been some reports of dry ejaculation during the period of AMICAR (aminocaproic acid) treatment. These have been reported to date only in hemophilia patients who received the drug after undergoing dental surgical procedures. However, this symptom resolved in all patients within 24 to 48 hours of completion of therapy.