AMICAR (aminocaproic acid) is generally well tolerated. The following adverse experiences have been reported:
General
Edema, headache, malaise.
Hypersensitivity Reactions
Allergic and anaphylactoid reactions, anaphylaxis.
Cardiovascular
Bradycardia, hypotension, peripheral ischemia, thrombosis.
Gastrointestinal
Abdominal pain, diarrhea, nausea, vomiting.
Hematologic
Agranulocytosis, coagulation disorder, leukopenia, thrombocytopenia.
Musculoskeletal
CPK increased, muscle weakness, myalgia, myopathy (see WARNINGS), myositis, rhabdomyolysis.
Neurologic
Confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope.
Respiratory
Dyspnea, nasal congestion, pulmonary embolism.
Skin
Pruritis, rash.
Special Senses
Tinnitus, vision decreased, watery eyes.
Urogenital
BUN increased, renal failure. There have been some reports of dry ejaculation during the period of AMICAR (aminocaproic acid) treatment. These have been reported to date only in hemophilia patients who received the drug after undergoing dental surgical procedures. However, this symptom resolved in all patients within 24 to 48 hours of completion of therapy.