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Nausea and headache, gastrointestinal distress, syncope, vomiting, hypotension, and other symptoms and signs of hypersensitivity have occurred. Cardiac arrest, basilar artery ischemia, severe shock, convulsions, and thrombophlebitis at the injection site and rare cases of death have been reported. Extravasation of the solution at the injection site causes intense pain at the site and a dull aching pain in the injected arm. (SEE WARNINGS.) Generalized hives and itching, bronchospasm and anaphylaxis have been reported. A strong taste may develop after injection.

The most common reaction is nausea.