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Deaths or serious or severe adverse events attributed to Prussian blue insoluble have not been reported. Constipation was reported in 10/42 (24%) patients in the Goiânia accident treated with Prussian blue insoluble. Severity of constipation was mild in 7 patients and moderate in 3 patients. Constipation was successfully treated with a high fiber diet.

Undefined gastric distress was reported in 3 patients treated with 20 gram/day of Prussian blue insoluble. In these patients the dose was reduced to 10 gram/day for continued treatment.