In controlled clinical trials for the management of acne vulgaris, the occurrence of adverse reactions associated with the use of Klaron (sodium sulfacetamide lotion) Lotion was infrequent and restricted to local events. The total incidence of adverse reactions reported in these studies was less than 2%. Only one of 105 patients treated with Klaron (sodium sulfacetamide lotion) Lotion had adverse reactions of erythema, itching and edema. It has been reported that sodium sulfacetamide may cause local irritation, stinging and burning. While the irritation may be transient, occasionally, the use of medication has to be discontinued.