Included in the listing that follows are adverse reactions that have not been reported with this specific drug; however, the pharmacologic similarities among the sulfonamides require that each of the reactions be considered with Gantanol (sulfamethoxazole) administration.
Hematologic: Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, hemolytic anemia, purpura, hypoprothrombinemia, methemoglobinemia, neutropenia, eosinophilia.
Allergic Reactions: Anaphylaxis, allergic myocarditis, serum sickness, conjunctival and scleral injection, generalized allergic reactions. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported.
Dermatologic: Stevens-Johnson syndrome, epidermal necrolysis, erythema multiforme, exfoliative dermatitis, photosensitivity, pruritus, urticaria, rash, generalized skin eruptions.
Gastrointestinal: Hepatitis, hepatocellular necrosis, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.
Genitourinary:Creatinine elevation, toxic nephrosis with oliguria and anuria. The frequency of renal complications is considerably lower in patients receiving the more soluble sulfonamides.
Neurologic: Convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache.
Psychiatric: Hallucinations, depression, apathy.
Endocrine: The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides) and oral hypoglycemic agents. Cross-sensitivity may exist with these agents. Diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides.
Musculoskeletal: Arthralgia, myalgia.
Respiratory: Pulmonary infiltrates.
Miscellaneous: Edema (including periorbital), pyrexia, chills, weakness, fatigue, insomnia.