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Systemic effects have been reported rarely following administration of 100 mcg of Factrel (gonadorelin) .

CNS:   headache, light-headedness.

GI:   nausea, abdominal discomfort.

Dermatologic:   local swelling, occasionally with pain and pruritis, at the injection site may occur following subcutaneous administration; local and generalized skin rash have been noted after chronic subcutaneous administration.

Cardiovascular:   flushing.

Rare instances of hypersensitivity reaction (bronchospasm, tachycardia, flushing, urticaria, induration at injection site) and anaphylactic reactions have been reported following multiple-dose administration.

There has been a report of pituitary apoplexy and sudden blindness following gonadotropin-releasing hormone administration to a patient with a gonadotropin-secreting adenoma.

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