Careful observation should be made for severe cholinergic reactions in the hyperreactive individual. The myasthenic patient in crisis who is being tested with Enlon (edrophonium injection) ® should be observed for bradycardia or cardiac standstill and cholinergic reactions if an overdose is given.
The following reactions common to anticholinesterase agents may occur, although not all of these reactions have been reported with the administration of Enlon (edrophonium injection) ®, probably because of its short duration of action and limited indications:
Increased lacrimation, pupillary constriction, spasm of accommodation, diplopia, conjunctival hyperemia.
|CNS:||Convulsions, dysarthria, dysphonia, dysphagia.|
Increased tracheobronchial secretions, laryngospasm, bronchiolar constriction, paralysis of muscles of respiration, central respiratory paralysis.
Arrhythmias (especially bradycardia), fall in cardiac output leading to hypotension. Increased salivary, gastric and intestinal secretion, nausea, vomiting, increased peristalsis, diarrhea, abdominal cramps.
|Skeletal Muscle:||Weakness, fasciculations.|
|Miscellaneous:||Increased urinary frequency and incontinence, diaphoresis.|