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Hypervitaminosis D is characterized by effects on the following organ system:


Impairment of renal function with polyuria, nocturia, polydipsia, hypercalciuria, reversible azotemia, hypertension, nephrocalcinosis, generalized vascular calcification, or irreversible renal insufficiency which may result in death.


Mental retardation.

Soft Tissues

Widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs.


Bone demineralization (osteoporosis) in adults occurs concomitantly.

Decline in the average rate of linear growth and increased mineralization of bones in infants and children (dwarfism), vague aches, stiffness, and weakness.


Nausea, anorexia, constipation.


Mild acidosis, anemia, weight loss.