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Local pain and tenderness at the injection site, urticaria, and angioedema may occur. Anaphylactic reactions, although rare, have been reported following the injection of human immune globulin preparations.6,9 Anaphylaxis is more likely to occur if BayGam (immune globulin) is given intravenously; therefore, BayGam (immune globulin) must be administered only intramuscularly.