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Mild transitory headache, dizziness and flushing of the face are common with the use of amyl nitrite (amyl nitrite inhalant) . The following adverse reactions may occur in susceptible patients: syncope, involuntary passing of urine and feces, hypotension, pallor, cold sweat, tachycardia, restlessness, weakness, vomiting and nausea. Excessively high doses of amyl nitrite (amyl nitrite inhalant) administered chronically may cause methemoglobinemia.

Drug abuse and dependence:

Abuse - Volatile nitrites are abused for sexual stimulation, with headache as a common side effect.

Dependence - Tolerance to nitrites can develop; conditions and duration have not been established.