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In the clinical trials with Amcinonide Lotion, the investigators reported a 4.7% incidence of side effects. In a weekly acceptability evaluation, approximately 20 % of the patients treated with Amcinonide Lotion or placebo reported itching, stinging, soreness, or burning at one or more of the visits.The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae and miliaria.